Takayuki Ariga | Graduate School of Medicine, Yamaguchi University

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Self introduction

Takayuki Ariga, Ph.D

Department of Genomics and Molecular Analysis, Graduate School of Medicine, Yamaguchi University

Associate professor (specially appointed)

Email: ariga(@)yamaguchi-u.ac.jp

See Reserchmap in detail.

Japanese page is here.

Research

We are researching
(1) Nonequilibrium energetics of biomolecular motors by using single-molecule manipulation and
(2) Mechanobiology to measure the mechanical properties of cells and tissues.

Our goal is to discover new physics in living organisms through manipulation and measurement on multiple levels,
from single molecules to organs.

(1) Nonequilibrium energetics of biomolecular motors by using single-molecule manipulation

Single molecule manipulation microscope
with optical tweezers (Click to enlarge)

We are studying Energetics of a biomolecular motor, kinesin, by using a single-molecule manipulation microscope (right figure) combined with optical tweezers.

Check out the following articles for the latest researches.

Research blog (Japanese):PRL論文公開・ニュースリリースしました
Press Release (Japanese):歩行型生体分子モーターのエネルギー入出力を解明・ (PDF in japanese)

Related Publications:

T. Ariga*, M. Tomishige, and D. Mizuno, Phys. Rev. Lett. 121, 218101 (2018) DOI, Sci-Hub
有賀隆行, 富重道雄, 水野大介, 生物物理 59,300-304 (2019) DOI
T. Ariga*, M. Tomishige, and D. Mizuno, Biophys. Rev. 12, 503-510 (2020) DOI, Sci-Hub (Review paper)
T. Ariga*, K. Tateishi, M. Tomishige, and D. Mizuno, arXiv preprint, 2012.04214 (2021) DOI ←NEW!!

(2) Mechanobiology to measure the mechanical properties of cells and tissues.

Magnetic field control unit
(Click to enlarge)

In collaboration with Mizuno Lab. at Kyushu University, we measured the mechanical properties of the cells and found that the inside of the cells fluctuated violently.

Press Release (Japanese):生きた細胞内部レオロジーを直接測定する手法を開発～未解明な点の多い細胞内力学の理解向上に期待～

Here, we are developping a recently established measurement method by using ferrofluid oil droplets to measure mechanical properties of organs/tissues (right figure).

Related Publications: